Abstract Background The human immunodeficiency virus Vif protein overcomes the inhibitory activity of the APOBEC3G cytidine deaminase by prohibiting its packaging into virions.Inhibition of APOBEC3G encapsidation is paralleled by a reduction of its intracellular level presumably caused by the Vif-induced proteasome-dependent degradation of APOBEC3G
Traveller-associated high-level ciprofloxacin-resistant Salmonella enterica Serovar Kentucky in the Republic of Korea
Objective: Salmonella enterica serotype Kentucky ST198 (S.Kentucky) is frequently associated with human infections and has been identified in travellers to North Africa, South Asia, Europe, and North America.The antimicrobial resistance of this serotype to multiple drugs, including ciprofloxacin (CIP), is a growing concern.However, little informati
Silver (I) N-Heterocyclic Carbenes Carbosilane Dendritic Systems and Their Imidazolium-Terminated Analogues as Antibacterial Agents: Study of Their Mode of Action
Spherical dendrimers and dendrons containing silver(I) N-heterocyclic carbenes (Ag(I)-NHC) and additionally bow-tie metal-free dendritic systems were synthesized in a simple and straightforward synthetic procedure and subsequently characterized.The antibacterial activity was evaluated, and in parallel, a comparative study with the cationic analogue
Medical professionalism: teaching and assessment tools
Establishing a structured curriculum for professionalism by click here adopting new methods and evaluation tools within an educational environment is important in the light of the vicissitudes of changing world and medical profession.By incorporating such tools of teaching and assessing, medical students will be abreast and gain a mastery over comp